The river that built the American West has run out of time. But the resourcefulness that built the American West is far from running dry. This report examines the biggest challenges to the Colorado River Basin, based on interviews with subject matter experts, reviews of scientific and news articles, and data provided by the Water Resilience Coalition. It also addresses the most promising strategies to mitigate them. Drawing on recent research and insights about ecology, water management and technology, it looks past the zerosum game of fighting over water allocations, and zeroes in on the emerging methods to keep the river running, together.